Apeloig studied at the École Supérieure des Arts Appliqués and the École Supérieure des Arts Décoratifs. In 1983 and 1985, he interned within the Total Design Studio in Amsterdam where his interest for typography was developed. In 1985, he was hired as a graphic designer by the Musée d’Orsay. In 1988, thanks to a grant from the French Ministry of Foreign Affairs, he went to Los Angeles to work with April Greiman. When he returned to Paris, he established his own studio.
In 1993 to 1994, he was granted a residency at the French Academy of Art in the Villa Medici in Rome where he carried out research into the design of letters. Back in Paris, he became a design consultant for the Louvre, and later became the museum's art director, a post he occupied from 2003 to 2008.
Apeloig has taught typography and graphic design at the École Nationale Supérieure des Arts Décoratifs in Paris from 1992 to 1999, and the Cooper Union School of Art in New York City from 1999 to 2002."
Throughout his career, Philippe Apeloig has worked with cultural institutions, publishing houses, and important luxury brands. He started in 1987 with the famous poster for the exhibition "Chicago, birth of a city", the first exhibition at the Musée d'Orsay. Since, he has created numerous posters for the Louvre, the Theatre du Châtelet, or the Fête du Livre in Aix-en-Provence. The publishing houses Robert Laffont and Phaidon Press often work with him.
He has created a number of logotypes including the ones of the Direction des Musées de France (2005), the Istituto Universitario di Architetture di Venezia (2004), the Petit Palais (2012). More recently, he has done the posters for exhibitions such as "Yves Saint Laurent" at the Petit Palais and for events such as the "Saut Hermès" at the Grand Palais in 2013. He is currently working on the signage for the upcoming Louvre Abu Dhabi with the HW / Atelier Jean Nouvel.
He is noted for his posters, many of which are in the collection of MoMA, and his typography, including the typefaces Octobre and Drop.